Fri Jan 13 2023

124 articles - From Friday Jan 06 2023 to Friday Jan 13 2023

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-analysis: Chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin.

Although statin and aspirin use were associated with reduced HCC risk, only statin use was significant in subgroup analyses accounting for concurrent medications. Metformin use was not associated with reduced HCC risk. These data have implications for future clinical trial design.

Pubmed   Journal   ReadQx 

Systematic review with meta-analysis: Time to diagnosis and the impact of delayed diagnosis on clinical outcomes in inflammatory bowel disease.

Delayed diagnosis is associated with disease progression in CD, and intestinal surgery in both CD and UC. Strategies are needed to achieve earlier diagnosis of IBD.

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Hepatology

Outcome of patients with hepatocellular carcinoma and liver dysfunction under Immunotherapy: a systematic review and meta-analysis.

The high heterogeneity across studies reflects the incapacity of the current evidence to support the indication of immunotherapy in HCC patients with relevant liver dysfunction. It is mandatory to report complementary information to Child-Pugh classification such as prior liver decompensation, use of concomitant medication to control ascites, or signs of clinically significant portal hypertension to allow better patient stratification in future studies.

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Telehealth interventions in patients with chronic liver diseases: a systematic review.

TH interventions in patients with CLD consistently show equivalent or improved clinical outcomes compared to traditional encounters. TH in CLD can bridge the gap in access while maintaining the quality of care for underserved populations.

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The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH): a systematic review.

NAFLD global prevalence is 30% and increasing which requires urgent and comprehensive strategies to raise awareness and address al aspects of NAFLD on local, regional, and global levels.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Original Article: prevalence and factors associated with liver fibrosis among first-degree relatives of Mexican Americans with hepatocellular carcinoma.

Using a well-phenotyped familial cohort, we found that the prevalence of significant fibrosis and definite hepatic steatosis are high in first-degree relatives of Mexican Americans with HCC, particularly those with diabetes, suggesting that this population may benefit from screening for liver disease.

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Prevalence of delayed gastric emptying in patients with gastroparesis-like symptoms.

In tertiary care patients who reported gastroparesis or FD symptoms, the presence of delayed GE was associated with GPLS. In patients with GPLS, delayed GE was associated with higher symptom severity.

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Am J Gastroenterol

Ambulatory pH-Impedance Findings Confirm that Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease.

Grade B esophagitis indicates an objective diagnosis of GERD.

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Association of Accelerometer-Measured Sedentary Behavior Patterns With Nonalcoholic Fatty Liver Disease Among Older Adults: The MIND-China Study.

Shorter sedentary time, engaging more frequent breaks in sedentary behavior, and replacing sedentary time with physical activity are associated with reduced likelihoods of NAFLD in older adults.

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Curative Management After Endoscopic Resection for Esophageal Squamous Cell Carcinoma Invading Muscularis Mucosa or Shallow Submucosal Layer-Multicenter Real-World Survey in Japan.

pSM1 and LVI were risk factors for metastasis after ER for ESCC. To improve the survival, additional treatment immediately after ER, such as chemoradiotherapy or surgery, is effective in patients with these risk factors.

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Effect of Biologics on the Risk of Advanced-Stage Inflammatory Bowel Disease-Associated Intestinal Cancer: A Nationwide Study.

Biologic use was associated with a lower risk of advanced IBD-associated cancer in patients with UC but not with CD. The mechanism of cancer progression between UC and CD may be different and needs to be further investigated.

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Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn's Disease: A Post Hoc Analysis of the REACH Trial.

Higher postinduction infliximab concentrations are associated with both short-term and long-term favorable clinical outcomes in pediatric patients with CD. Tailoring dosing during induction to achieve higher infliximab exposure may lead to better outcomes in pediatric patients with CD.

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Increased Proportion of Colorectal Cancer in Patients With Ulcerative Colitis Undergoing Surgery in the Netherlands.

This nationwide pathology study demonstrated an increased proportion of surgery for CRC over the past 3 decades. We hypothesize that the expanding therapeutic armamentarium for UC leads to exhausting medical options and hence postponed colectomy. This, however, might be at the expense of an increased risk of CRC in the long term.

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Low level of hepatitis B viremia compared with undetectable viremia increases the risk of hepatocellular carcinoma in patients with untreated compensated cirrhosis.

Compared with patients with undetectable HBV DNA, those with compensated cirrhosis and LLV had a significantly higher risk of HCC. Antiviral treatment should be advised for these patients.

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Prevalence and Correlations of Gastrointestinal Symptoms With Endoscopic and Histologic Mucosal Healing in Crohn's Disease.

The 2-item patient-reported outcome measure for abdominal pain and stool frequency correlated weakly with endoscopic (Simple Endoscopic Score for Crohn's Disease; r = 0.17, 95% CI 0.08-0.26, P = 0.0003) and histologic disease activity (Global Histologic Disease Activity Score; r = 0.14, 95% CI 0.03-0.24, P = 0.015). Overall, gastrointestinal symptoms correlate poorly with endohistologic disease activity.

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Rapid Immunochromatography on Fresh Intestinal Biopsy Is Highly Accurate in Detecting Intestinal Antitransglutaminase Antibodies.

I-anti-TG2 can be detected with an immunochromatographic assay after simple mechanical lysis of fresh intestinal biopsy with very high diagnostic accuracy. The test is quick and easy to perform and can be widely available in any endoscopy unit. Its implementation would allow a better understanding of the prognostic value of I-anti-TG2 and help clinicians in cases of suspected CeD that are difficult to classify.

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Ursodeoxycholic Acid Treatment-Induced GLOBE Score Changes Are Associated With Liver Transplantation-Free Survival in Patients With Primary Biliary Cholangitis.

UDCA-induced changes in the GLOBE score were significantly associated with LT-free survival in patients with PBC. While the relative risk reduction of LT or death was stable, the absolute risk reduction was heavily dependent on the baseline prognosis of the patient.

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What Every Gastroenterologist Should Know About Gastrointestinal NETs.

Practitioners should examine these lesions carefully found on routine endoscopy. Obtaining accurate neuroendocrine tumors stage and grade is critical to patient assessment and management, and assistance from advanced endoscopists may be needed.

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Wide Variability in Dysplasia Detection Rate and Adherence to Seattle Protocol and Surveillance Recommendations in Barrett's Esophagus: A Population-Based Analysis Using the GIQuIC National Quality Benchmarking Registry.

These US population-based results can serve as a benchmark for quality initiatives and intervention trials aimed at improving outcomes for patients with BE.

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Clin Gastroenterol Hepatol

Association of HSD17B13 and PNPLA3 with liver enzymes and fibrosis in Hispanic/Latino individuals of diverse genetic ancestries.

Variation in HSD17B13 and PNPLA3 variants across genetic ancestry groups may contribute to differential risk for liver fibrosis among Hispanic/Latino individuals.

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Multiple negative faecal immunochemical tests reduce risk of advanced neoplasia in a colonoscopy surveillance program.

There was a low risk of advanced neoplasia after multiple rounds of negative FIT in above average-risk people undergoing surveillance with no neoplasia or nonadvanced adenoma at prior colonoscopy. This supports the use of interval FIT to personalize surveillance by lengthening colonoscopy intervals following multiple negative FIT results.

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Multitarget Stool DNA Testing Has High Positive Predictive Value for Colorectal Neoplasia on the Second Round of Testing.

Mt-sDNA test positive rate and PPV were similar between 1 st and 2 nd rounds of screening. These observations confirm the utility of a second round of mt-sDNA screening and may inform estimates of mt-sDNA effectiveness for CRC screening.

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Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study.

Ritlecitinib and brepocitinib induction therapies were more effective than placebo for the treatment of moderate to severe active UC, with an acceptable short-term safety profile. , Number NCT02958865.

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Endosc Int Open

Endoscopic resection of upper gastrointestinal lesions using the colonic Ovesco full-thickness resection device: Retrospective observational case series of 22 cases.

Upper gastrointestinal EFTR using the colonic Ovesco FTRD is feasible without pre-dilation of the upper esophageal sphincter or pylorus. This study further confirms acceptable efficacy and safety in upper gastrointestinal use.

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Endoscopic severity and classification of lesions with pan-enteric capsule endoscopy and ileocolonoscopy in ileocolonic Crohn's disease.

The agreement for SES-CD sub-scores is fair to moderate. CE could be an alternative to IC for the assessment of endoscopic severity in selected patients with suspected CD.

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Endoscopic submucosal dissection using an ultrathin endoscope for superficial pharyngeal cancer: a prospective feasibility study (with video).

ESD using an ultrathin endoscope is feasible for superficial pharyngeal cancers and has potential to be a safe and effective treatment option for these cancers.

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Hiatal hernia repair with transoral incisionless fundoplication versus Nissen fundoplication for gastroesophageal reflux disease: A retrospective study.

Concomitant HH repair with TIF is feasible and associated with lower early and serious AEs compared to LNF. Further comparative efficacy studies are warranted.

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Impact of changing diagnostic criteria on the diagnosis of serrated polyposis syndrome.

Most patients with SPS in our database met the diagnosis of SPS by both 2010 and 2019 criteria, with only 5 % to 10 % of patients in each cohort not meeting the alternative diagnostic criteria.

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Outcomes of patients with hepaticojejunostomy anastomotic strictures undergoing endoscopic and percutaneous treatment.

DBE-ERCP is an effective diagnostic and therapeutic tool in those with altered gastrointestinal anatomy and is associated with low complication rates.

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Endoscopy

Computer-aided diagnosis for optical diagnosis of diminutive colorectal polyps including sessile serrated lesions: a real-time comparison with screening endoscopists.

We have developed a CADx system that differentiated neoplastic from non-neoplastic diminutive polyps during endoscopy with an accuracy comparable to the accuracy of screening endoscopists, with near-perfect technical efficacy.

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Effect of an automated flexible endoscope channels brushing system on improving reprocessing quality: a randomized controlled study.

AECBS could effectively reduce bioburden and improve reprocessing quality of gastroscopes and colonoscopes. It has great potential to replace manual brushing and lower the risk of endoscopy-associated infections, providing a new idea for the optimization of reprocessing.

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Gastroenterology

Anti-integrin avß6 autoantibodies are a novel biomarker that antedate ulcerative colitis.

Finally, high anti-avß6 was associated with a composite of adverse UC-outcomes including hospitalization, disease extension, colectomy, systemic steroid use and/or escalation to biologic therapy in recently diagnosed UC. Anti-integrin avß6 auto-antibodies precede the clinical diagnosis of UC by up to 10 years and are associated with adverse UC-related outcomes.

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Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric COMT/miR-155/TNF-a Axis.

Decreased colonic COMT in PI-IBS-D patients drives abdominal pain phenotypes via the COMT/miR-155/TNF-a axis. These important findings will allow new treatment paradigms and more targeted and personalized medicine approaches for gastrointestinal disorders following enteric infections.

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F4/80+Ly6Chigh macrophages lead to cell plasticity and cancer initiation in colitis.

We have identified CD11b+F4/80+Ly6Chigh macrophages as key mediators of cancer initiation in colitis-associated cancer. Development of new therapies that target these cells may provide an effective preventative strategy for colitis-associated cancer.

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Variation in testing for and incidence of celiac autoimmunity in Canada: A population-based study.

Incidence of celiac autoimmunity is high and increasing, despite stable testing rates. Variation in testing patterns may lead to underreporting the incidence of celiac autoimmunity in non-metropolitan areas and more socioeconomically deprived neighbourhoods.

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Gut

Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis.

Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the T in AP may help to ameliorate the disease course.

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Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study.

Antibiotic exposure is associated with an increased risk of IBD, and was highest among individuals aged 40 years and older. This risk increased with cumulative antibiotic exposure, with antibiotics targeting gastrointestinal pathogens and within 1-2 years after antibiotic exposure.

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Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis.

GDM onset can be identified in the first trimester of pregnancy, earlier than currently accepted. Furthermore, the gut microbiome appears to play a role in inflammation-induced GDM pathogenesis, with interleukin-6 as a potential contributor to pathogenesis. Potential GDM markers, including microbiota, can serve as targets for early diagnostics and therapeutic intervention leading to prevention.

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Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN.

CRC is a highly frequent cancer worldwide, and largely preventable through changes in modifiable risk factors, alongside the detection and removal of precancerous lesions. With increasing rates in transitioning countries and younger adults, there is a pressing need to better understand and act on findings to avert future cases and deaths from the disease.

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Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis.

Design Microbiota profiling in patients with RA and healthy individuals was investigated via 16S rDNA bacterial gene sequencing and shotgun metagenomics. Collagen-induced arthritic mice and TNF-a transgenic mice were used to evaluate the roles of the gut commensal and ginsenoside Rg2 might represent probiotic and prebiotic agents in the treatment of RA.

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Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis.

Expression of PNLIP p.T221M in a preclinical mouse model results in CP caused by ER stress and proteotoxicity of misfolded mutant PNLIP.

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S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.

Altogether, our results uncovered that S100A10 promotes HCC progression significantly via its transfer in EVs and regulating the protein cargoes of EVs. EV-S100A10 may be a potential therapeutic target and biomarker for HCC progression.

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Hepatology

Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome.

The intestinal virome of MAFLD patients who consume low to moderate amounts of alcohol are significantly different from those who do not, and many features of the intestinal virome of alcohol-consuming MAFLD patients resembles that of AUD patients.

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Budesonide as first-line treatment in patients with autoimmune hepatitis seems inferior to standard predni(so)lone administration.

In the real-life setting, the use of budesonide as first-line treatment is low, and it is generally prescribed to patients with perceived less disease activity. Budesonide was inferior to prednisone as a first-line drug but was associated with fewer side effects.

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CAP and LSM as determined by VCTE are independent predictors of all-cause mortality in the U.S. adult population.

Our study findings highlight the importance of liver health as a predictor of overall mortality at a population level.

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Checkpoint inhibitor hepatotoxicity: pathogenesis and management.

Based on the existing literature, we propose evolving management approaches to incorporate strategies to limit excess corticosteroid exposure, and address rare but important presentations of cholestatic hepatitis and fulminant liver failure. Finally, as ICI hepatotoxicity frequently occurs in the context of treatment for advanced malignancy, we review the impact of hepatotoxicity and its treatment on cancer outcomes, and the overall safety of re-challenge with ICI, for patients who may have limited treatment options.

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Conventional type 1 dendritic cells protect against gut barrier disruption via maintaining A. muciniphila in alcoholic steatohepatitis.

This study demonstrated that cDC1s protect alcohol-induced liver injury by maintaining A. muciniphila abundance in mice. Targeting cDC1s may serve as a promising therapeutic approach for treating ALD.

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Diabetes and cirrhosis: Current concepts on diagnosis and management.

Management is conditioned by whether the patient has either compensated or decompensated cirrhosis. This review gives an update on the complex relationship between cirrhosis and T2DM, with a focus on its diagnosis and treatment, and highlights knowledge gaps and future directions.

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Environmental eustress promotes liver regeneration via the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice.

The study findings support the brain-liver axis and suggest that environment-induced eustress promotes liver regeneration through the sympathetic nerve/ILC1/IL-22 axis.

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Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.

Given the robust preclinical data, several PPARa agonists have been tested in clinical trials for liver fibrosis. Here, we provide an update on recent progress in understanding the mechanisms by which PPARa prevents fibrosis and discuss the potential of targeting PPARa for the development of antifibrotic treatments.

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Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish.

Hepatocyte-to-BEC conversion occurs through transdifferentiation independently of proliferation, and Notch and Yap signaling control the process in parallel with a mutually positive interaction. The new zebrafish model will further contribute to a thorough understanding of the mechanisms of the conversion process.

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Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the United States.

In the U.S. population, gallstone disease prevalence doubled over 3 decades, possibly due to worsening of metabolic risk factors and growth of laparoscopic cholecystectomy. Gallbladder and biliary tract mortality and gallstone disease associations included factors such as prediabetes or diabetes, liver stiffness and proton pump inhibitors.

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Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression.

Loss of hepatocytes and increased ductular reaction are tightly associated with monocyte-derived macrophage accumulation and represent the most prominent common immunological feature revealing the progression of NAFLD, PSC, PBC and AH, suggesting IBA1 + CD163 low macrophages are key pathogenic drivers of human liver disease progression across diverse etiologies.

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Metabolic reprogramming and its clinical implication for liver cancer (HEP-22-1008).

We discuss metabolism of non-alcoholic fatty liver disease (NAFLD) as well, because NAFLD will likely become a leading etiology of liver cancer in the coming years due to the obesity epidemic in the Western world. Furthermore, we outline the clinical implication of liver cancer metabolism and highlight the computation and systems biology approaches, such as genome-wide metabolic models, as a valuable tool allowing us to identify therapeutic targets and develop personalized treatments for liver cancer patients.

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Metabolic reprogramming and its clinical implication for liver cancer.

We discuss metabolism of non-alcoholic fatty liver disease (NAFLD) as well, because NAFLD will likely become a leading etiology of liver cancer in the coming years due to the obesity epidemic in the Western world. Furthermore, we outline the clinical implication of liver cancer metabolism and highlight the computation and systems biology approaches, such as genome-wide metabolic models, as a valuable tool allowing us to identify therapeutic targets and develop personalized treatments for liver cancer patients.

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Mid-line 1 interacting protein 1 promotes cancer metastasis via FOS like 1-mediated matrix metalloproteinase 9 signaling in HCC.

Our study identified MID1IP1 as a regulator in promoting FRA1 mediated-MMP9 signaling and demonstrated its role in HCC metastasis. Targeting MID1IP1-mediated FRA1 pathway may serve as a potential therapeutic strategy against HCC progression.

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Nicotinamide N-methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.

These data highlight the critical role of NNMT in GBC progression. Inhibition of NNMT by JBSNF-000088 is a potential molecular target for GBC immunotherapy.

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Organelle stress and alterations in inter-organelle crosstalk during liver fibrosis.

An improved understanding of the organelle-level regulation of fibrosis can help devise effective anti-fibrotic therapies focused on reducing organelle stress, limiting organelle damage, improving inter-organelle crosstalk, and restoring organelle homeostasis; and could be a potential clinical option to avoid transplantation. This review provides a timely update on the recent findings and mechanisms covering organelle-specific dysfunctions in liver fibrosis, highlights how correction of organelle functions opens new treatment avenues and discusses the potential challenges to clinical application.

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Outcome of untreated low-level viremia vs. antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis.

Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared to Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research.

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Portal hypertension and variceal bleeding in patients with liver cancer: Evidence gaps for prevention and management.

Appropriate evaluation and treatment of PHT remain major issues in improving the outcomes of HCC patients. Many questions remain unanswered, opening the field to many areas of research.

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Regulatory MAIT cells controlled by ß1 adrenergic receptor signaling contribute to hepatocellular carcinoma progression.

Together, we reveal an immunosuppressive subset of MAIT cells in HCC patients that contributes to HCC progression, and propose a control through neuro-immune crosstalk.

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SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/ ß-catenin signaling.

Collectively, our findings revealed that SERPINA12 is preferentially overexpressed in epithelial HCC CD133+cells and is a key contributor to HCC initiation and progression by driving an AKT/ß-catenin feed-forward loop.

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SULT2B1-CS-DOCK2 axis regulates effector T cell exhaustion in hepatocellular carcinoma microenvironment.

This study indicates that DOCK2 controls CD8+ T cell infiltration in HCC, and CS synthesized by SULT2B1 in tumor cells promotes effector T cell exhaustion. The findings suggest that the usage of conventional drugs affects immunotherapy efficacy in HCC patients.

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Targeting VPS72 inhibits ACTL6A/MYC axis activity in hepatocellular carcinoma progression.

This study reveals the molecular mechanism of ACTL6A/VPS72/MYC in HCC, providing a theoretical basis and therapeutic target for this malignancy.

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The evolving role of liver sinusoidal endothelial cells in liver health and disease.

This article will review four broad advances in our understanding of LSEC biology in general 1) LSEC heterogeneity, 2) LSEC aging and senescence, 3) LSEC role in liver regeneration, and 4) LSEC role in liver inflammation and will then review the role of LSECs in various liver pathologies including fibrosis, drug-induced liver injury, alcohol-associated liver disease, non-alcoholic steatohepatitis, viral hepatitis, liver transplant rejection, and ischemia-reperfusion injury. The review will conclude with a discussion of gaps in knowledge and areas for future research.

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TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.

TWEAK/FN14 signaling activation in Prom1-expressing HPCs contributes to proliferation of profibrogenic ductular reactions in biliary atresia.

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J Hepatol

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models.

Boosting CD8 T cells was important to finally control HBV in these mouse models. Our findings provide important insights into the rational design of therapeutic vaccines to cure chronic hepatitis B.

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J Neurogastroenterol Motil

Clinical Characteristics of Patients With Ineffective Esophageal Motility by Chicago Classification Version 4.0 Compared to Chicago Classification Version 3.0.

IEM under CCv4.0 has a stronger association with pathologic reflux, especially supine reflux, and inadequate peristaltic reserve, but impairment in bolus clearance is unchanged when compared with IEM diagnosed based on CCv3.0. Further studies are required to determine the implications of these findings on management strategies.

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Diarrhea-predominant Irritable Bowel Syndrome-like Symptoms in Patients With Quiescent Crohn's Disease: Comprehensive Analysis of Clinical Features and Intestinal Environment Including the Gut Microbiome, Organic Acids, and Intestinal Permeability.

Minimal inflammation is closely associated with the development of IBS-D-like symptoms in patients with quiescent CD.

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Disorders of Gut-Brain Interaction in a National Cohort of Children With Down Syndrome.

DGBIs are common in children with DS and are associated with diminished QoL.

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Esophageal Hypocontractile Disorders and Hiatal Hernia Size Are Predictors for Long Segment Barrett's Esophagus.

The presence of a hypocontractile motility disorder increased the risk for LSBE. Furthermore, the risk for LSBE was directly associated with the length of the hiatal hernia.

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Lactase Deficiency Diagnosed by Endoscopic Biopsy-based Method is Associated With Positivity to Glucose Breath Test.

A questionnaire on gastrointestinal symptoms, a hydrogen (H is common in patients with severe LD suspected lactose intolerance. SIBO may be a new therapeutic target for managing intestinal symptoms in patients with lactose intolerance.

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Nutrient Drink Test to Assess Gastric Accommodation in Cyclic Vomiting Syndrome: Single-blinded Parallel Grouped Prospective Study.

To our knowledge, this is the first NDT protocol in CVS evaluating the role of impaired gastric accommodation and hypersensitivity as a possible pathophysiologic mechanism. Findings from this study suggest the presence of gastric hypersensitivity in a subset of CVS patients. These results provide the foundational data necessary for future larger testing of NDT and diagnostic accuracy in CVS.

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The Stressed Gut: Region-specific Immune and Neuroplasticity Changes in Response to Chronic Psychosocial Stress.

Unpredictable psychological chronic stress induces region-specific impairment in monoamine levels and neuroplasticity markers that may relate to delayed intestinal transit.

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Validation of Pharyngeal Acid Reflux Episodes Using Hypopharyngeal Multichannel Intraluminal Impedance-pH.

Our preliminary data showed that 80.0% (71.0-87.0%) of the proposed candidate PAR episodes were HMII-pH-proven PAR episodes, among which the interobserver reproducibility was good.

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Neurogastroenterol Motil

A randomized, double-blind, placebo-controlled, phase 2b study of the efficacy and safety of velusetrag in subjects with diabetic or idiopathic gastroparesis.

Velusetrag treatment was generally well-tolerated and associated with improved GE vs placebo in subjects with diabetic or idiopathic gastroparesis; however, only the lowest dose, velusetrag 5 mg, was associated with short-term improvement in gastroparesis symptoms. Clinicaltrials GOV NCT02267525.

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Impact of Rome IV criteria on the prevalence of post-infection irritable bowel syndrome.

Rome IV criteria resulted in a 19% lower prevalence of PI-IBS than earlier reported Rome III-based prevalence in a similar population. Rome IV defined PI-IBS patients have greater symptom severity but similar distribution of IBS subtypes.

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Novel sensory trigger for gastrocolonic response.

Visualizing or smelling food resulted in a significant increase in baseline MI in more than 50% of patients. Our findings propose a novel, alternate pathway that can induce GCR. This central sensory pathway may have clinical relevance in the diagnosis and management of patients with colonic dysmotility.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Therapeutic Drug Monitoring for Subcutaneous Infliximab? Too early to conclude.

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Gastroenterology

ARTIFICIAL INTELLIGENCE-AIDED COLONOSCOPY FOR CHARACTERIZING AND DETECTING COLORECTAL POLYPS: REQUIRED, NICE-TO-HAVE, OR OVER-HYPED?

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Lysosomes promote cancer metastasis via exosome in PTEN deficient tumors.

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J Hepatol

Rational Combination Therapy for NASH: Insights from Clinical Trials and Error.

In light of recent, negative, late stage trials of monotherapies, well designed combination development programs are essential to avoid additional failures that may hold back therapeutic research and access to treatment for patients. Enthusiasm for combination therapies should be maintained but realistically balanced against the complexity of the demonstration of their therapeutic value.

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J Neurogastroenterol Motil

Disorders of Gut-Brain Interaction in Children With Down Syndrome.

Pubmed   Journal   ReadQx 

Length of the Barrett's Esophagus Is Proportional to the Abnormality of Esophageal Motility and Anti-reflux Barrier.

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Nighttime Acid Reflux in Gastroesophageal Reflux Disease - Is It a Problem That Can Be Solved?

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Physiology of the Digestive Tract Correlates of Vomiting.

The retch mixes the gastric contents with acid neutralizer and gives momentum to the expelled bolus. During vomitus expulsion the esophagus is maximally stretched longitudinally which stiffens its wall to allow rapid transport as the suprahyoid muscles and diaphragmatic dome contract, and the hiatal fibers relax.

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Role of Endoscopy in Motility Disorders of Upper Gastrointestinal Tract.

Moreover, interventional endoscopy may be a primary or alternative treatment option for selected patients with motility disorders, and it is becoming a promising field as new therapeutic applications are developed and utilized for various motility disorders. This review may provide suitable indications for the use of endoscopy in diagnosing and treating motility disorders of the upper gastrointestinal tract.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Practical Guide to Use of Risankizumab.

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Esophageal Bulla in Epidermolysis Bullosa.

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Clin Gastroenterol Hepatol

Hepatic Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Mimicking Hepatocellular Carcinoma.

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How to Get Involved With Community Engagement, Community Service, and Patient Advocacy During GI Fellowship.

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Endoscopy

Artificial intelligence in endoscopic assessment of ulcerative colitis: virtual painting with PICaSSO.

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Pathologic sm2 carries a moderate risk of metastases even without other unfavorable factors, but positive horizontal margins have low local recurrence risk after en bloc resection.

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Wide-area transepithelial sampling of Barrett's epithelium: "WATS" the benefit?

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Gastroenterology

Continuation of Tumour Necrosis Factor Antagonists for Inflammatory Bowel Diseases During Pregnancy.

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Nociceptive nerve-microbiota crosstalk during inflammation: trying to restore intestinal homeostasis.

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Real-world implications of the AGA NAFLD Clinical Care Pathway in the US adult population.

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Targeting the enteric nervous system to treat constipation in Parkinson's disease.

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The Immune Ghosts of Pandemics Past.

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Unexpected abdominal wall varices After Split-liver Transplantation.

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Gastrointest Endosc

Top Tips for EUS-guided evaluation and sampling of pancreatic cystic lesions.

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Top Tips: Pancreatic Duct Strictures.

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Gut

'Invisible' immune checkpoint molecule causing resistance to anti-PD1 therapy in HCC.

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GI snapshot: weight loss and altered bowel habit in a 72-year-old woman.

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Hepatology

Can a mucosal microbiota signature predict disease severity, survival, and disease recurrence in PSC?

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Editorial in Hepatology Urine: A place where HEV cannot hide!

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Evaluating the risk-benefit ratio of immunotherapy according to liver-functional reserve in advanced hepatocellular carcinoma: the dark side of the moon.

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HBV, mitochondrial stress and liver fibrosis: chicken or the egg.

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Introducing Norah Terrault, MD, MPH, Our 2023 AASLD President.

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Is embolization of large spontaneous shunt effective in the prevention of hepatic encephalopathy after TIPS?

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Is it a prime time for germline genetic testing for hepatocellular carcinoma?

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January 2023 Hepatology Highlights.

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January 2023 Hepatology Highlights.

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Letter to the Editor Learning more about the safety of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma.

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Letter to the editor: Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: A case-control study.

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March 2023 Hepatology Highlights.

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Much more needed in natural history of Alagille syndrome.

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Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.

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Using global burden of hepatocellular cancer and liver cirrhosis as a driver to tackle preventable mortality and morbidity nationally and regionally.

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J Neurogastroenterol Motil

The Differential Outcomes of Peroral Endoscopic Myotomy and Pneumatic Dilatation Upon Subtypes of Achalasia Indicate Pathophysiological Differences in Morphological Change of Esophageal Body.

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Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Comment on "Food processing and risk of Crohn's disease and ulcerative colitis: A European Prospective Cohort Study": Author's reply.

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J Hepatol

From coagulation imbalance to prediction of advanced chronic liver disease decompensation: the wind of change?

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Genetic factors in the clinical predictive model for hepatocellular carcinoma: Evidence from genetic association analyses.

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Survival benefit of adequate lymphadenectomy in patients undergoing liver resection for clinically node negative intrahepatic cholangiocarcinoma - Letter to the editor.

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